Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A
Identifieur interne : 000C34 ( Main/Exploration ); précédent : 000C33; suivant : 000C35Mimotopes selected with neutralizing antibodies against multiple subtypes of influenza A
Auteurs : Yanwei Zhong [République populaire de Chine] ; Jiong Cai [République populaire de Chine] ; Chuanfu Zhang [République populaire de Chine] ; Xiaoyan Xing [République populaire de Chine] ; Enqiang Qin [République populaire de Chine] ; Jing He [République populaire de Chine] ; Panyong Mao [République populaire de Chine] ; Jun Cheng [République populaire de Chine] ; Kun Liu [République populaire de Chine] ; Dongping Xu [République populaire de Chine] ; Hongbin Song [République populaire de Chine]Source :
- Virology Journal [ 1743-422X ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps antiviraux (sang), Anticorps neutralisants (immunologie), Banque de peptides, Femelle, Humains, Immunisation, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Mimétisme moléculaire (immunologie), Poumon (anatomopathologie), Poumon (virologie), Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Séquence d'acides aminés, Test ELISA, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (), Virus de la grippe A (immunologie), Épitopes (), Épitopes (administration et posologie), Épitopes (immunologie).
- MESH :
- administration et posologie : Vaccins antigrippaux, Épitopes.
- anatomopathologie : Poumon.
- immunologie : Anticorps antiviraux, Anticorps neutralisants, Infections à Orthomyxoviridae, Mimétisme moléculaire, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux, Virus de la grippe A, Épitopes.
- sang : Anticorps antiviraux.
- virologie : Poumon.
- Animaux, Banque de peptides, Femelle, Humains, Immunisation, Infections à Orthomyxoviridae, Souris, Souris de lignée BALB C, Séquence d'acides aminés, Test ELISA, Tests d'inhibition de l'hémagglutination, Virus de la grippe A, Épitopes.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (blood), Antibodies, Viral (immunology), Enzyme-Linked Immunosorbent Assay, Epitopes (administration & dosage), Epitopes (chemistry), Epitopes (immunology), Female, Hemagglutination Inhibition Tests, Humans, Immunization, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza A virus (classification), Influenza A virus (immunology), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Lung (pathology), Lung (virology), Mice, Mice, Inbred BALB C, Molecular Mimicry (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (prevention & control), Peptide Library.
- MESH :
- chemical , administration & dosage : Epitopes, Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- chemical , chemistry : Epitopes.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Epitopes, Influenza Vaccines.
- classification : Influenza A virus.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A virus, Molecular Mimicry, Orthomyxoviridae Infections.
- pathology : Lung.
- prevention & control : Orthomyxoviridae Infections.
- virology : Lung.
- Amino Acid Sequence, Animals, Enzyme-Linked Immunosorbent Assay, Female, Hemagglutination Inhibition Tests, Humans, Immunization, Mice, Mice, Inbred BALB C, Peptide Library.
Abstract
The mimotopes of viruses are considered as the good targets for vaccine design. We prepared mimotopes against multiple subtypes of influenza A and evaluate their immune responses in flu virus challenged Balb/c mice.
The mimotopes of influenza A including pandemic H1N1, H3N2, H2N2 and H1N1 swine-origin influenza virus were screened by peptide phage display libraries, respectively. These mimotopes were engineered in one protein as multi- epitopes in Escherichia coli (E. coli) and purified. Balb/c mice were immunized using the multi-mimotopes protein and specific antibody responses were analyzed using hemagglutination inhibition (HI) assay and enzyme-linked immunosorbent assay (ELISA). The lung inflammation level was evaluated by hematoxylin and eosin (HE).
Linear heptopeptide and dodecapeptide mimotopes were obtained for these influenza virus. The recombinant multi-mimotopes protein was a 73 kDa fusion protein. Comparing immunized infected groups with unimmunized infected subsets, significant differences were observed in the body weight loss and survival rate. The antiserum contained higher HI Ab titer against H1N1 virus and the lung inflammation level were significantly decreased in immunized infected groups.
Phage-displayed mimotopes against multiple subtypes of influenza A were accessible to the mouse immune system and triggered a humoral response to above virus.
Url:
DOI: 10.1186/1743-422X-8-542
PubMed: 22171803
PubMed Central: 3320565
Affiliations:
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Le document en format XML
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Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qin, Enqiang" sort="Qin, Enqiang" uniqKey="Qin E" first="Enqiang" last="Qin">Enqiang Qin</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Jing" sort="He, Jing" uniqKey="He J" first="Jing" last="He">Jing He</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, 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neutralizing antibodies against multiple subtypes of influenza A</title><author><name sortKey="Zhong, Yanwei" sort="Zhong, Yanwei" uniqKey="Zhong Y" first="Yanwei" last="Zhong">Yanwei Zhong</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cai, Jiong" sort="Cai, Jiong" uniqKey="Cai J" first="Jiong" last="Cai">Jiong Cai</name><affiliation wicri:level="3"><nlm:aff id="I2">Department of Nuclear Medicine, PUMC Hospital, PUMC & CAMS, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Nuclear Medicine, PUMC Hospital, PUMC & CAMS, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Chuanfu" sort="Zhang, Chuanfu" uniqKey="Zhang C" first="Chuanfu" last="Zhang">Chuanfu Zhang</name><affiliation wicri:level="3"><nlm:aff id="I3">Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xing, Xiaoyan" sort="Xing, Xiaoyan" uniqKey="Xing X" first="Xiaoyan" last="Xing">Xiaoyan Xing</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Qin, Enqiang" sort="Qin, Enqiang" uniqKey="Qin E" first="Enqiang" last="Qin">Enqiang Qin</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Jing" sort="He, Jing" uniqKey="He J" first="Jing" last="He">Jing He</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cheng, Jun" sort="Cheng, Jun" uniqKey="Cheng J" first="Jun" last="Cheng">Jun Cheng</name><affiliation wicri:level="3"><nlm:aff id="I4">Liver Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Liver Center, Beijing Ditan Hospital, Capital Medical University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Kun" sort="Liu, Kun" uniqKey="Liu K" first="Kun" last="Liu">Kun Liu</name><affiliation wicri:level="3"><nlm:aff id="I3">Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><affiliation wicri:level="3"><nlm:aff id="I1">Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Pediatric Liver Disease Research Laboratory, Institute of Infectious Diseases, Beijing 302 Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Song, Hongbin" sort="Song, Hongbin" uniqKey="Song H" first="Hongbin" last="Song">Hongbin Song</name><affiliation wicri:level="3"><nlm:aff id="I3">Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">Virology Journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (blood)</term><term>Antibodies, Viral (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Epitopes (administration & dosage)</term><term>Epitopes (chemistry)</term><term>Epitopes (immunology)</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Immunization</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Lung (pathology)</term><term>Lung (virology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Molecular Mimicry (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (prevention & control)</term><term>Peptide Library</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (immunologie)</term><term>Banque de peptides</term><term>Femelle</term><term>Humains</term><term>Immunisation</term><term>Infections à Orthomyxoviridae ()</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Mimétisme moléculaire (immunologie)</term><term>Poumon (anatomopathologie)</term><term>Poumon (virologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term><term>Séquence d'acides aminés</term><term>Test ELISA</term><term>Tests d'inhibition de l'hémagglutination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (immunologie)</term><term>Épitopes ()</term><term>Épitopes (administration et posologie)</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Epitopes</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Epitopes</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term><term>Infections à Orthomyxoviridae</term><term>Mimétisme moléculaire</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus</term><term>Molecular Mimicry</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Hemagglutination Inhibition Tests</term><term>Humans</term><term>Immunization</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Peptide Library</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Banque de peptides</term><term>Femelle</term><term>Humains</term><term>Immunisation</term><term>Infections à Orthomyxoviridae</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Séquence d'acides aminés</term><term>Test ELISA</term><term>Tests d'inhibition de l'hémagglutination</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The mimotopes of viruses are considered as the good targets for vaccine design. We prepared mimotopes against multiple subtypes of influenza A and evaluate their immune responses in flu virus challenged Balb/c mice.</p></sec><sec><title>Methods</title><p>The mimotopes of influenza A including pandemic H1N1, H3N2, H2N2 and H1N1 swine-origin influenza virus were screened by peptide phage display libraries, respectively. These mimotopes were engineered in one protein as multi- epitopes in Escherichia coli (E. coli) and purified. Balb/c mice were immunized using the multi-mimotopes protein and specific antibody responses were analyzed using hemagglutination inhibition (HI) assay and enzyme-linked immunosorbent assay (ELISA). The lung inflammation level was evaluated by hematoxylin and eosin (HE).</p></sec><sec><title>Results</title><p>Linear heptopeptide and dodecapeptide mimotopes were obtained for these influenza virus. The recombinant multi-mimotopes protein was a 73 kDa fusion protein. Comparing immunized infected groups with unimmunized infected subsets, significant differences were observed in the body weight loss and survival rate. The antiserum contained higher HI Ab titer against H1N1 virus and the lung inflammation level were significantly decreased in immunized infected groups.</p></sec><sec><title>Conclusions</title><p>Phage-displayed mimotopes against multiple subtypes of influenza A were accessible to the mouse immune system and triggered a humoral response to above virus.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ekiert, Dc" uniqKey="Ekiert D">DC Ekiert</name></author><author><name sortKey="Bhabha, G" uniqKey="Bhabha G">G Bhabha</name></author><author><name sortKey="Elsliger, Ma" uniqKey="Elsliger M">MA Elsliger</name></author><author><name sortKey="Friesen, Rh" uniqKey="Friesen R">RH Friesen</name></author><author><name sortKey="Jongeneelen, M" uniqKey="Jongeneelen M">M Jongeneelen</name></author><author><name sortKey="Throsby, M" uniqKey="Throsby M">M Throsby</name></author><author><name sortKey="Goudsmit, J" uniqKey="Goudsmit J">J 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Chine"><noRegion><name sortKey="Zhong, Yanwei" sort="Zhong, Yanwei" uniqKey="Zhong Y" first="Yanwei" last="Zhong">Yanwei Zhong</name></noRegion><name sortKey="Cai, Jiong" sort="Cai, Jiong" uniqKey="Cai J" first="Jiong" last="Cai">Jiong Cai</name><name sortKey="Cheng, Jun" sort="Cheng, Jun" uniqKey="Cheng J" first="Jun" last="Cheng">Jun Cheng</name><name sortKey="He, Jing" sort="He, Jing" uniqKey="He J" first="Jing" last="He">Jing He</name><name sortKey="Liu, Kun" sort="Liu, Kun" uniqKey="Liu K" first="Kun" last="Liu">Kun Liu</name><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><name sortKey="Qin, Enqiang" sort="Qin, Enqiang" uniqKey="Qin E" first="Enqiang" last="Qin">Enqiang Qin</name><name sortKey="Song, Hongbin" sort="Song, Hongbin" uniqKey="Song H" first="Hongbin" last="Song">Hongbin Song</name><name sortKey="Xing, Xiaoyan" sort="Xing, Xiaoyan" uniqKey="Xing X" first="Xiaoyan" last="Xing">Xiaoyan Xing</name><name sortKey="Xu, Dongping" sort="Xu, Dongping" uniqKey="Xu D" first="Dongping" last="Xu">Dongping Xu</name><name sortKey="Zhang, Chuanfu" sort="Zhang, Chuanfu" uniqKey="Zhang C" first="Chuanfu" last="Zhang">Chuanfu Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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